“The medaka Kiyosu panel: dissecting GxE effects of environmental chemicals”
In this proposal we have assembled an international, multi-disciplinary team to exploit a unique resource, the wild-derived inbred Kiyosu panel of medaka (Japanese rice-paddy) fish to investigate how environmental exposures have a variable impact on individuals through genetic variation Here we investigate “Gene x Environment” (GxE) effects to both quantify phenotypic changes and importantly gain mechanistic, molecular understanding of the biological pathways involved in contaminant responses in cardiovascular and skeletal toxicity.
Ewan Birney, European Molecular Biology Laboratory
Jochen Wittbrodt, University of Heidelberg
Jared Goldstone, Woods Hole Oceanographic Institution