“The medaka Kiyosu panel: dissecting GxE effects of environmental chemicals”
In this proposal we have assembled an international, multi-disciplinary team to exploit a unique resource, the wild-derived inbred Kiyosu panel of medaka (Japanese rice-paddy) fish to investigate how environmental exposures have a variable impact on individuals through genetic variation Here we investigate “Gene x Environment” (GxE) effects to both quantify phenotypic changes and importantly gain mechanistic, molecular understanding of the biological pathways involved in contaminant responses in cardiovascular and skeletal toxicity.
Collaborators include:
Ewan Birney, European Molecular Biology Laboratory
Jochen Wittbrodt, University of Heidelberg
Jared Goldstone, Woods Hole Oceanographic Institution